Background: The relationship between infection with human papillomavirus (HPV) and tumorigenesis of salivary gland remains controversial. Objectives: This study explored the relationship between HPV and salivary gland lesions as well as that of the HPV infection status and p16 INK4A immunoreactivity. The HPV DNA loads were also quantitatively evaluated.
Although several studies have reported that oropharyngeal infection with HPV may predispose to tumorigenesis, little is known about the etiological factors of salivary gland tumors and the presence of HPV.
This study demonstrated a very low human papillomavirus detection rate in salivary gland tumours. It can therefore be concluded that human papillomavirus infection is unlikely to play a role in salivary gland neoplasia. Rare human papillomavirus positive cases should be carefully evaluated to exclude the possibility of a metastatic lesion.
Human papillomavirus (HPV) HPV is the name of a very common group of viruses. They do not cause any problems in most people, but some types can cause genital warts or cancer. HPV affects the skin.
Little is known about the role of human herpes virus 8 (HHV-8), Epstein-Barr virus (EBV), and human papillomavirus (HPV) infection in salivary gland neoplasms. We investigated the presence of the three viruses in formalin-fixed, paraffin-embedded tissue samples in a cohort of 200 different salivary gland tumours.
The apical portion of the tumor was a papillomatous lesion. Histological examination of the resected tumor led to a diagnosis of sebaceous gland hyperplasia. Human papillomavirus-51 was detected in the apical portion by in situ hybridization. Based on these results, the final diagnosis was sebaceous gland hyperplasia with papilloma.
BACKGROUND: Salivary gland malignancies are a very heterogeneous group of cancers, with histologically > 20 different subtypes, and prognosis varies greatly. Their etiology is unknown, however, a few small studies show presence of human papillomavirus (HPV) in some subtypes, although the evidence for HPV having a causal role is weak. The aim of this study was to investigate if HPV plays a …
OBJECTIVE: The roles of human papillomavirus (HPV) and Epstein-Barr virus (EBV) in head and neck neoplasms have been well reported, but little is known about their relationship with salivary gland tumours. This study investigated the presence of HPV and EBV in salivary gland diseases. METHODS: The presence of HPV 16/18 and EBV was analysed in archival pathological specimens collected from …
The human papillomavirus, or HPV, is another factor that pushes the dial toward cancer. HPV is known for its risk for genital warts, but people can also develop HPV in their mouth or throat. That can lead to squamous cell cancer in the mouth or throat that can cause enlarged lymph nodes.
Salivary gland cancer. Salivary gland cancer can start in any of the glands that make spit (saliva). As well as 3 major pairs of salivary glands we have over 600 smaller, minor salivary glands throughout the lining of the mouth and throat.