Doses of 25 (Nguyen et al., 1999) or 100 (Gillen et al., 1999) mg/kg DHEA do not alter the content of dopamine or its metabolites either in the occipital cortex, cerebellum, striatum or midbrain 2 h post-administration. Those results suggest that DHEA-induced increase in dopamine content at the dose of 25 mg/kg is region-dependent.
DHEA is a “youthful” androgen hormone responsible for vitality, muscle tone, libido, energy, bone density and memory. DHEA increases neuronal excitability, modulate neuronal plasticity and is neuroprotective to the brain. (8) DHEA balances excess cortisol seen in stress.
Chronic DHEA experimental models of PD (Chen et al., 2007; Sagi et al., 2007; administration (2 mg/kg) increases DA and 5-HT content in the rat Youdim and Bakhle, 2006) as well as in other paradigms of cell NAc, while DOPAC/DA, HVA/DA and 5-HIAA/5-HT ratios tended to damage (Mandel et al., 2005; Stefanova et al., 2008). Furthermore, decrease but were not signiﬁcantly different to control …
Dietary dehydroepiandrosterone (DHEA) reduces food intake in mice, and this response is under genetic control. Moreover, both food restriction and DHEA can prevent or ameliorate certain diseases and mediate other biological effects.
DHEA-S uses genomic, slow, long-lasting mechanisms to do so by upregulating tyrosine hydroxylase levels, the enzyme responsible for dopamine production. DHEA, on the other hand, signals to increase dopamine levels in rapid, intense, short-lived bursts.
It has been shown that the steroid dehydroepiandrosterone (DHEA) interacts with dopamine (DA) and serotonin (5-HT) neurotransmitter systems, which are involved in the pathophysiology of neurological and psychiatric diseases such as Parkinson’s disease as well as mood and psychotic disorders.
DHEAS also modulates dopamine and serotonin release in hippocampal neurons (Zajda et al, 2012). As these four regions are key to emotion regulation and episodic memory (Hofmann et al, 2012), they…
Lazaridis et al. have shown that DHEA binds to the NGF receptor . So it is possible that BDNF could provide the receptors for DHEA too. The decreased levels of NGF and BDNF are found to decrease trkA receptor and a loss of cholinergic neurons . The pharmacologically induced strengthening of the cholinergic system may play a role in alleviating age-associated dysfunctions. 5. Conclusion. DHEA …
DHEA antagonizes the effects of cortisol. DHEA is a very powerful anti-aging hormone. Low levels of DHEA are found among those with Cancer, CVD, Alzheimer’s, Diabetes, Depression, Hypothyroidism and Adrenal Fatigue. Since cortisol and DHEA have opposing effects, they should be viewed together as a ratio.
L-DOPA is a Dopamine Precursor L-DOPA is a direct precursor of dopamine – it is the compound that dopamine is made from. It gets converted to dopamine by the enzyme aromatic amino acid decarboxylase (AADC or AAAD), which is active both in the bloodstream and in the brain [ 1 ].