Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D 3 (abbreviated 25(OH)D 3), is a prehormone which is produced in the liver by hydroxylation of vitamin D 3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase.This metabolite is measured, together with 25(OH)D 2 (ercalcifediol), to determine an individual’s vitamin D status.
The reaction first occurs in the liver and converts vitamin D to 25-hydroxyvitamin D [25 (OH)D], also known as calcidiol. The second occurs primarily in the kidney and forms the physiologically active 1, 25-dihydroxyvitamin D [1,25 (OH)2D], also known as calcitriol.
Vitamin D (ergocalciferol -D2, cholecalciferol -D3, alfacalcidol) is a fat -soluble vitamin that helps your body absorb calcium and phosphorus. Having the right amount of vitamin D, calcium, and…
Calcifediol is a vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Calcifediol is used to treat hyperparathyroidism (overactive parathyroid glands) in people who have stage 3 or 4 chronic kidney failure and low vitamin D levels.
Initially 250 nanograms daily, adjusted in steps of 250 nanograms every 2-4 weeks if required; usual dose 0.5-1 microgram daily. Renal osteodystrophy (in patients with normal or only slightly reduced plasma-calcium concentration)
Calcifediol is a vitamin D3 analog that is used to treat secondary hyperparathyroidism in adult patients with stage 3 or 4 chronic kidney disease and serum total 25-hydroxyvitamin D levels less than 30 ng/mL. Hyperparathyroidism is a condition that is caused when the parathyroid glands located in the neck make too much parathyroid hormone (PTH).
Initially 1 microgram daily, dose to be adjusted to avoid hypercalcaemia; maintenance 0.25-1 microgram daily.
Alfacalcidol is a type of vitamin D. You will need to have regular blood tests while you are taking the medicine so that your doctor can adjust your dose. Make sure you know the symptoms of too much calcium in your blood – these are losing your appetite, feeling thirsty, being sick, feeling tired and losing weight.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021 …
Alfacalcidol is converted rapidly in the liver to 1,25-dihydroxyvitamin D. This is the metabolite of vitamin D which acts as a regulator of calcium and phosphate metabolism. Since this conversion is rapid, the clinical effects of One-Alpha and 1,25-dihydroxyvitamin D are very similar.